Exercise training prevents Ca dysregulation in coronary smooth muscle from diabetic dyslipidemic yucatan swine
نویسندگان
چکیده
Departments of Medical Pharmacology and Physiology and Internal Medicine, and the Center for Diabetes & Cardiovascular Health, University of Missouri, Columbia, Missouri; Department of Molecular Physiology and Biological Physics, and the Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia; and Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana
منابع مشابه
Exercise training prevents Ca2+ dysregulation in coronary smooth muscle from diabetic dyslipidemic yucatan swine.
Aerobic exercise training is known to have profound cardioprotective effects in disease, yet cellular mechanisms remain largely undefined. We tested the hypothesis that increased sarcoplasmic reticulum Ca(2+) buffering and increased voltage-gated Ca(2+) channel density underlie coronary smooth muscle intracellular Ca(2+) (Ca(2+)(i)) dysregulation in diabetic dyslipidemia and that exercise train...
متن کاملExercise prevents diabetes-induced impairment in superficial buffer barrier in porcine coronary smooth muscle.
In healthy coronary smooth muscle cells, the superficial sarcoplasmic reticulum (SR) buffers rise in intracellular Ca(2+) levels. In diabetic dyslipidemia, basal Ca(2+) levels are increased, yet Ca(2+) influx is decreased and SR Ca(2+) uptake is increased. Exercise prevents diabetic dyslipidemia-induced increases in basal Ca(2+) levels and decreases in Ca(2+) influx. We tested the hypothesis th...
متن کاملHIGHLIGHTED TOPIC Mechanism of Beneficial Effects of Physical Activity on Atherosclerosis and Coronary Heart Disease Ca regulatory mechanisms of exercise protection against coronary artery disease in metabolic syndrome and diabetes
Sturek M. Ca regulatory mechanisms of exercise protection against coronary artery disease in metabolic syndrome and diabetes. J Appl Physiol 111: 573–586, 2011. First published May 19, 2011; doi:10.1152/japplphysiol.00373.2011.— Chronic exercise attenuates coronary artery disease (CAD) in humans largely independent of reductions in risk factors; thus major protective mechanisms of exercise are ...
متن کاملIncreased endothelin-induced Ca2+ signaling, tyrosine phosphorylation, and coronary artery disease in diabetic dyslipidemic Swine are prevented by atorvastatin.
Endothelin-1 (ET-1) signaling mechanisms have been implicated in the pathogenesis of excess coronary artery disease in diabetic dyslipidemia. We hypothesized that in diabetic dyslipidemia ET-1-induced coronary smooth muscle calcium (Ca2+m) and tyrosine phosphorylation would be increased, and the lipid lowering agent, atorvastatin, would inhibit these increases. Male Yucatan miniature swine grou...
متن کاملDiabetic dyslipidemia and exercise affect coronary tone and differential regulation of conduit and microvessel K+ current.
Spontaneous transient outward K(+) currents (STOCs) elicited by Ca(2+) sparks and steady-state K(+) currents modulate vascular reactivity, but effects of artery size, diabetic dyslipidemia, and exercise on these differentially regulated K(+) currents are unclear. We studied the conduit arteries and microvessels of male Yucatan swine assigned to one of three groups for 20 wk: control (C, n = 7),...
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تاریخ انتشار 2006